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2000 Anti-Premarin, animal rights protest poster. Text reads: "I may be the only girl in my high school going through menopause, but I'm not dumb enough to drink horse urine! Premarin, the most widely prescribed menopause drug, is actually made from pregnant mares' urine (PMU). Its production causes misery and death for tens of thousands of horses and the foals every year. That's why it's the ONE drug you'll never find in my locker. Check out the alternatives by visiting www.MenopauseOnline.com. Amy Sedaris as Jerri Blank on Comedy Central's "Strangers With Candy."